Shimadzu LCMS-IT-TOF
Hybrid High Performance LCMS-ion trap-time-of-flight mass spectrometer
First of its kind, the solutions to all the unknowns!
Featuring MSn Capability
Shimadzu's new LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research, and ideal for applications in forensics, drug development, and environmental chemistry. Coupling atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight (TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy and high mass resolution (10,000 at 1000 m/z) independent of MS mode.
The LCMS-IT-TOF allows more qualitative information about a sample to be collected in a single run.
This enables researchers and scientists to:
· Elucidate structures of new molecules
· Identify impurities and contaminants
· Analyze metabolites and biomarkers to evaluate biological pathways
The LCMS-IT-TOF has been designed to maximize sensitivity and selectivity by optimizing the ion transport to the TOF analyzer and redefining the capability of the quadrupole ion trap. The ion trap is used to focus ions before ejection into the TOF as well as supporting MSn analysis with effective precursor ion selection capabilities (resolution > 1,000 at 1,000 m/z).
The new instrument incorporates a host of new technologies and enhancements, including:
· Compressed Ion Injection (patented)
· Ballistic Ion Extraction (patent pending)
· Dual-Stage Reflectron (patent pending)
· New ion transfer optics
· Temperature control of the flight tube
The source design, desolvation capillary and reduced collision ion focusing Q-Array were adapted from Shimadzu's successful single-quad HPLC mass spectrometer.
Combining new, innovative technologies with one of the fastest polarity switching speeds available, the LCMS-IT-TOF expands the power of mass spectrometry scanning to deliver unparalleled performance for the most demanding analytical needs.The advantages associated with the use of TOF include not only its high resolution and high sensitivity, but also its high mass accuracy. The higher the mass accuracy, the easier it is to narrow the composition candidates of unknown compounds and, as a result, the easier it becomes to deduce the formula of the compound.
Moreover, these data were acquired using only an external standard for mass calibration of the TOF. Also, mass calibration using the LCMS-IT-TOF required only 15 minutes.
From the above, it can be seen that the LCMS-IT-TOF provides highly stable high resolution and high-mass accuracy in all MSn modes. It is an ideal LCMS for structural elucidation, enabling high-speed analysis and high-speed polarity switching for analysis of sharp chromatographic peaks.
Software applications
Awards
1. Winner of the 2005 R&D 100 Award
2. Winner of the 2005 Pittcon Editors’ Silver Award
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LCMS-IT-TOF 
